Endocrine Abstracts

Context: A variety of thyroid disorders have been documented in COVID-19 patients, including non-thyroidal illness syndrome (NTIS), subacute thyroiditis (SAT) and thyrotoxicosis.Objectives: To investigate the relationship between thyroid dysfunctions observed during hospitalisation and COVID-19-related morbidity and mortality.Study design and setting: Prospective cohort study on patients admitted in a tertiary hospital for COVID-19...

Several synthetic peptide and non-peptide ligands of the GHS-R1a have been described that release GH and stimulate food intake. Starting from a triazole scaffold, we have designed and prepared novel small molecules with high binding affinity to the GHS-R1a and we have investigated their effects in vitro on free intracellular calcium levels and in vivo on food intake and GH secretion in the rat. In CHO cells transfected with the GHS-R1a, hexarelin stimulated calcium leve...